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It has been previously shown that DGCR8 binds r CGG exp and forms a scaffold for the binding of other proteins such as Sam68 and hnRNP.
The methylation of lysine 9 in histone H3 is recognized by HP1; this methylation directs the binding of other proteins to control chromatin structure and gene expression.
We describe here a Förster resonance energy transfer (FRET -based approach FRET -basedng in vitro the rapproachextent oforilameasuringatinn from septin complexes, binding of other proteins to septin structures, and the apparent affinities of these interactions.
7SK serves as a structural scaffold for HEXIM1 and P-TEFb in the inhibitory complex, as well as for the binding of other proteins.
Once thought to be only molecular scaffolds that indirectly affect cellular functions through the binding of other proteins, in vitro studies have shown their role as actin nucleators in the formation of new filaments.
However, we did not exclude the less likely possibility that the binding of other proteins to syntaxin, e.g., the binding of Munc 18 to assembled SANRE complexes containing syntaxin in the "open" conformation ([28] or Munc −13 which stabilizes the "open" conformation of syntaxin [29], [30], could be impaired and result in inhibition of Ca2+-triggered secretion.
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It has been proposed that RAP serves two critical functions with respect to these receptors, the first to ensure correct folding of their CR domains and the second to prevent premature tight binding of other protein ligands to the CR clusters within the ER [ 9, 12].
It is possible that some of the CNRs lie within true binding sites of other proteins that were not identified in this study.
We conjecture that these two TFs may be recruited to open chromatin in coding regions and increase the binding affinity of other proteins.
Some of these interactions might be mediated by the association of CFTR via its C-terminal PDZ-binding motif (D-T-R-L) with the PDZ-binding domains of other proteins, such as NHERF [ 11, 12, 20, 21].
This Dxxx DxxxD signature is different from DxDxDG calcium-binding regions of other proteins like the EF-hand protein family (Rigden and Galperin, 2004).
More suggestions(15)
binding of other mutants
binding of hnRNP proteins
binding of regulatory proteins
binding of nuclear proteins
binding of substrate proteins
binding of unfolded proteins
binding of mutant proteins
binding of Lig proteins
binding of other regulators
binding of other members
binding of soluble proteins
binding of other molecules
binding of universal proteins
binding of other ions
binding of iodinated proteins
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