Sentence examples for binding of natural from inspiring English sources

Due to the mutation of the LBD, only the synthetic ligand can bind, thereby circumventing binding of natural ligands that activate the construct.

FcγIIa and FcγIIIa possess polymorphisms that alter the binding of natural IgGs to those receptors.

Previous studies indicated that mutations of E45K in the first transmembrane domain (TMD), and K404L in the 11th TMD, produce selective and opposite alterations in binding of natural folate substrates to murine RFC.

Paramagnetic proteoliposomes, consisting of a paramagnetic bead surrounded by a lipid membrane containing CCR5 [32] or CXCR4 [33], have been used to study the binding of natural chemokine ligands and HIV-1 glycoproteinsoteins.

On view of the low dissociation rate of HS-γ-wt complexes, it can be speculated that the secreted, free form of the chemokine hardly would reach the equilibrium of interaction with immobilized HS and that under physiological conditions, the binding of natural CXCL12γ to extracellular HS structures is tight and long-lasting.

It is possible that, under these circumstances, the alternative pathway would be triggered by carbohydrates from the glycocalix of the intestinal cells and that the classical pathway would be triggered by unspecific binding of natural antibodies to these carbohydrates or other intestinal molecules.

Thus, we speculate that the observed IgE binding potential of batch B reflects the IgE binding capacity of natural Bet v 1.0401, whereas the low IgE binding activity of batch A seems rather artificial.

With the combination of pairwise decomposition energies and computational alanine scanning, the key amino acids in binding, TRP50, ASN52, GLU57, MET100, LYS101, ASN169, LEU185, LYS188, HIS228, and LEU229, were the important residues to binding efficiency of natural HIV epitope at the C-terminal on p17.

Here, we address these design issues by developing a computational model to simulate the dynamics and binding kinetics of natural and engineered fusion proteins such as antibody-cytokine complexes.

Although the experimental structures of dArmRP deviated from the designed curvature, the insertion of the most conserved binding pockets of natural ArmRPs onto the surface of dArmRPs resulted in binders against the expected peptide with low nanomolar affinities, similar to the binders from the consensus-design series.

VFTM of most of the class C GPCRs contains the binding site of natural amino acids or derivatives.