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In both the GcvB and RybB sRNAs, these regions are involved in the binding of multiple targets, which results in reduced translation of the targets (Vogel, 2009).
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It also sheds light on the side effects of drugs through anticipation of their multiple functions and similarities in the binding sites of multiple targets.
The MTLD contains all of the ligands binding to MTLs and sheds light on the side effects through anticipation of their multiple functions as well as the similarities in the binding site of multiple targets.
For living cells, the multivalency of secondary antibodies allows binding and bridging of multiple targets, potentially cross-linking primary antibodies, causing aggregation or stimulating biological responses.
Advances in antibody engineering technologies have resulted in a number of novel biopharmaceutical formats capable of binding to multiple targets.
However, loading of RNA PolII was clearly shown to precede Myc binding on multiple target promoters and in different cell types [25], [31], [32], [50], [66] (Fig. 7C).
For computational methods it is more difficult to study selectivity than activity because selectivity analysis requires the evaluation of compounds binding to multiple targets [2].
A flexible linker region between the two elongated hArc domains may allow them to move freely with respect to each other and confer the recognition of, and binding to, multiple targets.
Studying and predicting the target spectrum and specificity of any drug is important for determining potential polypharmacology (the modulation of multiple targets by a single compound) as well as evaluating possible drug toxicities (due to undesirable off-target binding).
(2) Calculate the similarity of multiple targets.
Combinations of kinase inhibitors, with each potentially binding to multiple targets, may be necessary to inhibit undesirable growth and proliferation signals active in neoplasms [35].
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