Zhu, C. & Williams, T. E. Modeling concurrent binding of multiple molecular species in cell adhesion.
We investigate the binding of multiple H atoms to one another, to interstitial C and to substitutional solutes.
Nature makes extensive use of polyvalency the simultaneous binding of multiple ligands to multiple complementary receptors.
The opening of calcium channels in the endoplasmic reticulum by the binding of multiple molecules of InsP3 provides the required cooperativity.
Vacancy-hydrogen interactions are described by a simple non-interacting thermodynamic model incorporating binding of multiple H atoms at vacancies, with energetics derived from first-principles calculations.
To do so we have focused on the concept of TF co-occupancy, in which synergy between TFs results from the binding of multiple TFs to common promoters and/or enhancers.
We found that single genetic variants frequently affect binding of multiple TFs, and CTCF can recruit all five TFs to its binding sites.
Future research directions point towards modeling cooperative binding of multiple orthosteric and allosteric ligands to GPCRs, GPCR oligomerization and interactions of GPCRs with different intracellular signaling proteins.
We then focused on 11 genes harboring ≥4 miRNA binding sites (Fig. 1b), since binding of multiple miRNAs to the same target gene can lead to co-regulation and stronger effects on target gene expression irrespective of the degree of miRNA changes20.
JBU has a bound phosphate and covalently modified residue (Cys592) by β-mercaptoethanol at its active site, and the concomitant binding of multiple inhibitors (phosphate and β-mercaptoethanol) is not observed so far in bacterial ureases.
These simulations demonstrate that simultaneous binding of multiple PIP molecules by PH domains contributes to high-affinity membrane interactions, informing our understanding of membrane recognition by PH domains in vivo.
