Sentence examples for binding of masitinib from inspiring English sources

Consequently, preferred binding of masitinib by KIT is observed.

Binding of masitinib to ABL occurs in a similar manner, although small differences are observed near the DFG motif (Phe810 in KIT and Phe382 in ABL) (Figure 6C).

When docked into the KIT binding site, the aminothiazole of masitinib participates in a hydrogen bond with the side-chain of the gatekeeper residue Thr670.

The developed method was applied also to measure the rate of masitinib excretion in rat urine.

Dose of masitinib in rats were calculated using a specific conversion equation of drugs between animals [13 15].

Fresh dilutions of masitinib were made for each experiment.

Upon withdrawal of masitinib treatment after day 5, tumour growth was once again evident.

Finally, the effect of masitinib on primary BMMCs from mice expressing wild-type KIT was examined.

Future work will test the activity of masitinib on these kinases.

Our molecular modelling studies suggest that this greater selectivity of masitinib may be due to an inability to form hydrogen bonds to three water molecules in the active site of ABL, despite both compounds binding to the active sites of KIT and ABL with similar conformations [22].

To estimate the range of masitinib concentrations necessary to sensitise pancreatic tumour cell lines to chemotherapy, we assessed the ability of masitinib to block protein tyrosine phosphorylation by western blot analysis in cell lysates.