In the present study, an insight has been provided into the potential ligand binding activity of innate immune component of wild versus domestic ruminants through in silico characterization and comparative structural analysis of the partial conglutinin encoding the neck and carbohydrate recognition domain (NCRD) of blackbuck and goat.
Remarkably, alterations in the NF- κB pathway are mediated by transcriptional elongation mediated by enhanced phospho-Ser carboxy terminal domain (CTD) of RNA Pol II binding to innate gene promoters.
Mannose-binding lectin (MBL) activates the lectin-complement pathway of innate immunity through binding to repetitive sugar arrays on microbial surfaces [ 1].
The binding of soluble or secreted innate immune molecules on pathogen-associated molecular patterns (PAMPs) as well as apoptotic cell-associated molecular patterns (ACAMPs) provide several "eat me" signals to promote the safe disposal of the intruders by professional and amateur phagocytes.
VRP generate double-stranded RNA that stimulates innate immune responses through RNA binding receptors [22], [30], [31], potent inducers of innate antiviral responses, including type I IFNs [32].
SP-D is recognized as an important regulator of innate immunity capable of binding pathogens and facilitating phagocytosis [ 21].
Ficolins are carbohydrate-binding proteins related to collectins, a class of innate immunity lectins involved in the phagocytic ingestion of apoptotic cells [ 51- 53].
Defensins are antimicrobial peptides of innate immunity functioning by non-specific binding to anionic phospholipids in bacterial membranes.
The majority of plant resistance (R) genes encode a class of innate immune receptors (NLRs) with nucleotide binding and leucine-rich repeat domains.
These include guanine nucleotide binding proteins, innate immunity proteins, thioredoxins, components of the protein degradation pathway, transcription factors, and fructose-2,6-bisphosphatase, a regulatory enzyme of glycolysis.
