Sentence examples for binding of different ligands from inspiring English sources
For ALR2 and FGFR1, conformational changes in the binding site upon binding of different ligands were observed [30, 31].
As suggested by case study results, Pocket v.2 can yield consistent pharmacophore models for proteins with minor conformational changes upon binding of different ligands, indicating the robustness of the approach.
The binding of different ligands to extracellular domains triggers intracellular signaling reactions involved in cell differentiation, proliferation, and survival.
The distinct sensitivity to Kir3.1 channel inhibition in the inhibitory effects of oxycodone and morphine on IPSCs might be due to the distinct receptor conformationsand intracellular signalling imposed by binding of different ligands.
Moonlighting proteins perform two or more cellular functions, which are selected based on various contexts including the cell type they are expressed, their oligomerization status, and the binding of different ligands at different sites.
We hypothesized that insulin and IGF-II would exhibit different endocytosis dynamics and that these differences would give new insights on the divergence of signaling pathways that could be triggered from the same receptor upon binding of different ligands.
To investigate enzyme ligand interactions in yeast hexokinase isoform PII under physiological conditions, we utilized the technique of Saturation Transfer Difference NMR (STD NMR) to monitor binding modes and binding affinities of different ligands at atomic resolution.
Moreover, the model was able to predict the binding affinities of different ligands.
Moreover, it is able to predict binding affinities of different ligands from their induced signaling profiles.
As an example, an ODE model derived from a Boolean model of T cell activation has been shown to be able to reproduce time courses in response to different ligand concentrations and to predict binding affinities of different ligands [ 18].
We discuss how parameters for this model can be determined such that quantitative experimental results are explained and predicted, including time-courses for multiple ligand concentrations and binding affinities of different ligands.
