Sentence examples for binding of cofactor from inspiring English sources

Inhibition is competitive with the binding of cofactor.

The misfolded R173W mutation has also been shown to be catalytically deleterious, and it is assumed that the substitution of the arginine residue will lead to an improper binding of cofactor and substrate, resulting in blocking of catalysis [ 23, 26].

Substitution of Asp in the forty-ninth position interrupts the binding of cofactor Ca2+ to the Ca2+-binding loop, and hence "mutants" show low or no hydrolytic activity [ 10, 14, 15].

The first was a directed strategy aimed at protein residues not directly involved in either the binding of cofactor or the catalytic pocket, but dispersed throughout the protein, that might result in a range of impacts on protein function.

This protein contains the conserved catalytic tetrad found in AKRs, but its binding of cofactor is likely to be compromised, and with over half of the protein missing, it is predicted to be inactive, if expressed.

The association between receptor dimers and DNA response elements is enhanced by the binding of cofactor proteins, such as amplified in breast cancer-1, thyroid hormone receptor-associated protein, SRC-1, glutamate receptor interacting protein-1 and translation initiation factor 2 [ 55].

The structural and functional basis of the p97/valosin-containing protein (VCP -interacting motif (VCP -interactingxclusive binding of cofactors to the N-termotif domain of p97.

Two processes, folding of the protein and binding of cofactors, intermingle with each other, making the direct elucidation of the folding mechanism of proteins in the presence of cofactors challenging.

Some ways silicone oligomers and oils may alter enzyme activity include: interaction with the enzyme active site; encapsulation of the enzyme [30]; altering protein tertiary or quaternary structure by bulk interactions; and by binding of cofactors.

The binding of cofactors could have a direct effect on these ensembles.

In this study, we investigated how the binding of cofactors to the kinase domain of Ire1 modulates its RNase activity.