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For instance, 29Si NMR combined with cross polarization (1H 29Si) under magic angle spinning (CP-MAS) was used to investigate the binding of chemicals on clay surfaces [42 44].
3D modeling revealed a hot spot area formed by 3 binding sites, forces including hydrogen bonds and van der Waals interactions appear to play a significant role in enabling and stabilizing the binding of chemicals.
(1310) There seem to be no QSAR studies available yet for the binding of chemicals to G-actin.
Partitioning into erythrocytes and leukocytes was used to provide a picture about the binding of chemicals in the blood.
The binding of chemicals to both integral and peripheral membrane proteins leads to a decrease in the free concentration of chemicals, thus reducing all types of transport.
The binding of chemicals to proteins in plasma affects their availability to other tissues and their effective half-life in the body.
Similar(43)
The binding of chemical signals to their corresponding receptors induces events within the cell that ultimately change its behaviour.
At the same time polypharmacology, which refers to the binding of chemical compounds to more than one target, has also been intensively studied [2].
For protein binding ability of chemicals, results of peptide reactivity assays of DPRA/PPRA were collected.
These studies may help to understand the factors influencing the binding affinity of chemicals and to develop alternative methods for prescreening and designing of polo-like kinase inhibitors.
Data on the binding kinetics of chemicals to receptors from multiple species, in addition to toxicokinetic and toxicodynamic information, will be necessary to begin quantitatively predicting effects across species using HTS data.
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