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We observed that the combination of an L allele with an H allele (LH) correlates with strong DC-SIGN binding of breast milk.
Herrera-Gayol and Jothy [42] showed that CD44 variants (especially CD44v6) could regulate the binding of breast cancer cells to extracellular HA, and these binding interactions could mediate tumor cell metastasis.
Furthermore, binding of breast cancer cell-derived M-CSF promotes epithelial growth factor (EGF) production by macrophages.
On the other hand, sialyl Lewis-x is the representative carbohydrate involved in the E-selectin binding of breast, ovarian and pulmonary cancer cells [ 1].
Studies by Lewalle et al (1998) demonstrated that the binding of breast epithelial cells to HUVECs induced a transitory rise in HUVEC intracellular concentration of Ca2+ resulting in endothelial retraction and epithelial migration.
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We have used techniques that maintain cell viability (and hence exclude intracellular plg binding from the analyses) to confirm that the majority of plg binding on breast cancer cells is regulated by pln activity at the cell surface.
Taken together, these results suggested that sLex moieties are likely involved in mediating the binding interactions of breast cancer cells to E-selectin and that breast cancer cell transendothelial migration is positively correlated to the binding activity of the exE-selectin/Fc recombinant to tumor cells.
In the first part of this paper, docking method was employed in order to study the binding mechanism of breast cancer resistance protein (BCRP) with a group of previously synthesized TPS-A derivatives which known as potent inhibitors of this protein to get insight into drug binding site of BCRP and to explore structure activity relationship of these compounds.
Furthermore, we compared BSSL size variations with DC-SIGN binding capacity of breast milks.
We were able to correlate allelic polymorphisms in the BSSL gene with the DC-SIGN binding phenotype of breast milk.
The aim of this study was to characterize the DC-SIGN binding properties of breast milk derived from healthy breastfeeding mothers.
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