Sentence examples for binding of both ligands from inspiring English sources

The binding of both ligands to membranes of Sf9 cells expressing MC4 receptors was saturable and with high affinity.

As described above, crystallographic, kinetic, and equilibrium studies combined with allosteric analysis strongly imply a fundamental thermodynamic similarity in the cooperative binding of both ligands to HbI. Figure S2 of the Supporting Information shows the different spectra acquired for CO-bound and unbound HbI.

The method allowed for selecting the correct binding orientation of both ligands from four different orientations gained by rotation of the ligands in the binding pocket.

In addition a quantitative analysis of the STD data indicates that the binding pose of both ligands is similar in both proteins (Supporting Information).

We demonstrate extremely rapid binding kinetics of both ligands to phosphatidylserine (PtdSer -displaying ACs, and show that ACs can be co-oPtdSer -displayingiple PtdSer opsonins.

As can be seen, the CRT E217A and E223A mutants, but not mutants D220A, H224A, Y254A or N279A, showed significantly lower binding of both SE ligands.

One of these mutations (E282K) did not affect the binding of either AP-SEMA3A or AP-VEGF, while others (E282K and E420K) eradicated binding of both the ligands.

Note that the observed enthalpy (Δ H °obs) for the binding of both these ligands to HDAC8 becomes more favorable (i.e., its negative value increases) with an increase in temperature.

Incorporating conformational rearrangements of the receptor binding pocket into predictions of both ligand binding pose and binding score is crucial for improving structure-based drug design and virtual ligand screening methodologies.

Upon binding of its ligand, both receptors can activate several downstream pathways such as PI3-kinase and MAPK signalling, inducing cell proliferation and cell survival (Lewis et al, 1998; Bellamy et al, 1999; Grandage et al, 2005).

The more closed molecule of the complex dimer AB allows a tighter binding of ligands, reflected in both closer distances and increased electron densities between dUMP pyrimidine ring C6 atom and enzyme catalytic Cys189 γS atom in this molecule, suggestive of the presence of the C6- γS covalent bond in a fraction of mTS-dUMP-Raltitrexed molecules.