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The interaction of SCR and SHR initiates binding of both factors to the SCR promoter producing a positive feedback loop.
In these cases (Fig. 7), binding of both factors involved is required to mediate the biological function.
By co-immunoprecipitation and chromatin immunoprecipitation, we demonstrate physical association of HoxA-11 and FOXO1A, and binding of both factors to an enhancer region (−395 to −148 relative to the PRL transcriptional start site) of the decidual prolactin promoter.
This synergism requires the independent binding of both factors to different cis-elements in the Hahsp17.6G1 promoter [ 10].
Thus, the competitive interplay between BORIS and Sp1 does not seem to be caused by alternation of the DNA binding of both factors.
Moreover, the binding of both factors is necessary for the recruitment of transcription machinery on the ERBB2 gene promoter in BT-474 and SKBR3 cell lines.
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To determine whether common binding between Dichaete and SoxNeuro is conserved, we performed a detailed analysis of the binding patterns of both factors in two species.
A bioinformatics analysis of the Ogg1 gene locus identified several promoter sites containing NRF-1 and NRF-2α DNA binding motifs, and chromatin immunoprecipitation assays confirmed in situ binding of both transcription factors to the Ogg1 promoter within 24 hours of infection.
Most significantly, the SCIN binding site sterically occludes the binding sites of both factor H and factor B. Our results give insight into SCIN binding to activated derivatives of C3, explain how SCIN can recognize C3b in the absence of other complement components, and provide a structural basis for the competitive C3b-binding properties of SCIN.
The probability of GCN4 reinitiation via this sequence of events is the product of the probability of scanning past the uORF4 start codon without any factors with the probability of binding both factors afterwards: (20) P 3 (n 1, n 2 ) = P S 1 n 1 × ∑ i = 0 n 2 P S 1 i × P T C 1 × 1 - P S 2 n 2 - i + P X 1 × 1 - P S 3 n 2 - i.
DR1 requires the binding of both fetoprotein transcription factor (FTF) and hepatocyte nuclear factor (HNF 4α for transcriptional activation of its regulated genes.
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binding of both compounds
binding of both GTPases
binding of both dyes
binding of both forms
binding of both ligands
binding of both types
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binding of both groups
binding of both hybrids
binding of both mAbs
binding of both receptors
binding of both probes
binding of both linkers
binding of both toxins
binding of both disintegrins
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