Sentence examples for binding of an extracellular from inspiring English sources
The binding of an extracellular chemical signal to a cell surface receptor stimulates an enzyme complex in the membrane to produce cyclic AMP.
The transduction process begins with the binding of an extracellular signaling molecule to a cell-surface receptor.
On binding of an extracellular ligand of the extensive transforming growth factor (TGF) superfamily to its cognate receptor complex, latent cytoplasmic Dpc4 is activated and translocated into the nucleus to function as part of various DNA-binding transcriptional activator complexes.
Signal transduction involves the binding of an extracellular signalling molecule (ligand) to a specific cell-surface receptor.
GPCR signaling occurs through a series of sequential molecular interactions that begin with the binding of an extracellular agonist.
Although the EGF receptor is activated by binding of an extracellular ligand, it can be activated in the absence of an extracellular ligand via integrin signaling.
Even more, an initial observation with the camstatin peptide prompted us to hypothesise that antipsychotic inhibitors of calmodulin eliminate vanilloid-induced Ca2+-uptake due to binding to an extracellular domain of TRPV1.
Classically, cAMP signals are initiated by the binding of a specific extracellular ligand to a G-protein-coupled receptor (GPCR) that is linked to a heterotrimeric G-protein containing a Gαs subunit.
Macrophage adhesion through scavenger receptors is well-characterized, including binding of SR-A to extracellular matrix proteins, biglycan and decorin (19), glycated collagen IV (17), and β-amyloid (39), as well as adhesion of CD36 to myeloperoxidase-modified LDL (oxLDL) (62).
According to structures of active class-A GPCRs (Rasmussen et al., 2011), activation of the 7-TM domain by binding of an agonist on the extracellular side is through reorganization of the packing of the 7 TM helices and results in a large conformational change on the cytosolic side, enabling G-protein binding (Zhang et al., 2013).
