Sentence examples for binding of an extended from inspiring English sources
In particular, steric restrictions within the enzyme's active site (as discussed above) appear to disfavor the binding of an extended C1 substituent on the substrate.
These observations support the idea that mutation to smaller residues widens the cavity to allow for the binding of an extended isoprenoid tail, while mutation to bulkier residues hinders this ability.
Crystal structures of SH3 domains with two distinct non-canonical specificities revealed novel peptide-binding modes through an extended surface outside of the canonical proline-binding site.
HLA II binding peptides have an extended conformation at the binding groove unlike class I.
An analogous origin (AAV5) possesses a unique interaction between an extended Rep binding element and a 49 aa region of Rep containing two DNA binding interfaces.
Prediction of MHC class II ligands is complicated by the open binding cleft of the MHC class II molecule, allowing binding of peptides extending out of the binding groove.
Unique to Nav1.2, the binding of ABD-C extends all the way to R1 via charge charge and hydrogen-bond interactions.
The subsequently acting Hsp90 has an extended client-binding interface that enables a large number of low-affinity contacts.
The N-terminus of BBK32 contains a signal peptide followed by a "lipobox" and an extended intrinsically disordered segment (residues 21 205) that contains the Fn-binding sites [19].
In a classic paper in 1989 Driever and colleagues provided evidence that Bicoid could activate the expression of these genes and that higher affinity binding sites in the promoter of a gene extended its activation to lower levels of Bicoid [ 1].
