Sentence examples for binding of an appropriate from inspiring English sources

HREs bind nuclear hormone receptors that act as ligand-induced transcription factors following the binding of an appropriate steroid, hormone or vitamin, activating or suppressing gene transcription [ 97].

Similarly, the virus displaying the ZZ domains of protein A was targeted to BHK cells via binding of an appropriate IgG antibody.

The extrinsic pathway classically begins with the binding of an appropriate ligand to a subset of tumor necrosis factor (TNF) receptor superfamily (TNFRSF) members: the death receptors.

In the extrinsic pathway, cell death begins with the binding of an appropriate ligand to death receptors, such as tumor necrosis factor (TNF) receptors on the cell surface, and then caspases are activated including caspase-8 and caspase-3.

TLR's are comprised of two functionally significant domains; one for recognizing specific pathogen associated molecular patterns (PAMPs) and one for recruiting signalling adaptor proteins following binding of an appropriate pathogen-derived ligand.

The KGS strategy computes the binding affinity of a query ligand target complex based on the known binding affinity of an appropriate reference complex, which is required to share a similar pattern of key ligand target interactions to that of the query complex of interest.

For widespread use in medicine of any radioisotope, two factors are essential: availability of the isotope and a stable and effective mode of binding with an appropriate chemical carrier [ 4].

This work illustrates that ER ligands having simple amide core structures can be readily prepared, but that high affinity binding requires an appropriate distribution of bulk, polarity, and functionality.

However, it is possible that such experiments do not give the exhaustive list of sequences of binding sites, so one needs to expand the list of putative binding sites using an appropriate criterion, which brings about the problem of the generalization of several known examples.

The method of tight binding can be an appropriate way to calculate the localization of light as well as an efficient way in investigating disorders in the photonic crystals.

If the HER2 protein lacks the antibody binding domain (the truncated form of HER2 is also called p95), it is resistant to trastuzumab due to lack of an appropriate binding site.