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mDia formins remodel the actin cytoskeleton through binding of a variety of different Rho GTPases (Figure 3), and the specificity of the actin-rich structure is dictated by the association of distinct mDia:Rho GTPase pairs.
UV vis and 1H NMR spectroscopy has been utilized to detect the binding of a variety of anions such as the halides, dihydrogen phosphate, hydrogen sulfate, and acetate.
Why the binding of a variety of substrates can drive the transportation cycle, while inhibitor binding may stabilize them in only one of their two possible conformations.
Based on the parsed structures of ecMdfA, the key location for the binding of a variety of substrates was determined to be the large central cavity within MdfA, which is lined with mostly hydrophobic residues.
By introducing conservative and non-conservative substitutions at positions 34, 89 and 91, we have examined the binding of a variety of bacterial strains to the receptor constructs.
Strong association between chromatin accessibility and the binding of a variety of transcription factors has been observed [ 17] although it is difficult to separate cause and effect in studies on developmental tissues.
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It has been shown that Abi1 is capable of binding to a variety of signaling molecules involved in control of cell proliferation, apoptosis and cytoskeletal functions.
While protein contraction and reduced mobility, as demonstrated by computational and NMR techniques respectively, have been correlated to entropies of binding for a variety of systems, to our knowledge, Raman difference spectroscopy has never been included in these analyses.
We then characterized pneumococcal TFs capable of binding to a variety of up-regulated genes during pathogenesis and compared their activation profiles between D39, WCH16 and WCH43.
Additionally, α-dystroglycan subunit is capable of binding to a variety of laminin isoforms and the proteoglycan molecules agrin, perlecan and neurexins (2– 5).
Further in silico studies of AgamOBP1 binding to a variety of candidate ligands showed a preference for elongated cylindrical molecules with no side chains, but small flat ring structures can be accommodated in the binding site as well.
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