Sentence examples for binding of a unique from inspiring English sources

Heparin's anticoagulant activity is due to the binding of a unique pentasaccharide sequence (as shown in Fig.  1) containing a 3- O-sulfo moiety to the protease inhibitor antithrombin III, causing a conformational change that increases the flexibility of its reactive site loop and thus its binding affinities for thrombin and factors IXa and Xa [ 18, 19].

Binding of a unique heparin pentasaccharide to antithrombin III (AT-III) induces a conformation change in AT-III enhancing its affinity for thrombin and coagulation factors IXa and Xa.

PCR primers were tested In Silico using BLAT in UCSC to confirm their binding to a unique region of the genome and the absence of polymorphism.

Although binding or dissociation of a unique conjugate is measured by this sensitive technique, the signal observed is the summation of all simultaneous events.

Many simple motif extraction algorithms have been proposed primarily for extracting the transcription factor binding sites, where each motif consists of a unique binding site [ 4- 10] or two binding sites separated by a fixed number of gaps [ 11- 13].

The tetrameric folding of β-tryptase and the pair-wise distribution of its substrate binding sites offer a unique opportunity for development of inhibitors that span two adjacent binding sites.

Here, we review properties of these GPCR binding sites, using a unique combination of calculated physicochemical properties and water energetics (GRID, WaterMap and SZMAP) to provide a new perspective and rational assessment of druggability for each GPCR target binding site.

Of the three mammalian isoforms A-RAF is special in that one of its two lipid binding domains mediates a unique pattern of membrane localization.

The ant algorithm offers an efficient, reproducible procedure to predict a role of individual transcription-factor binding motifs using a unique definition of artificial ants.

It is possible that the branching of amylopectin actually hinders At5g39790 binding and reflects a unique feature of At5g39790 and this may play a role in defining its in vivo function.

Specifically, structural and biochemical analyses show that the second messenger c-di-GMP activates BldD DNA binding by driving a unique form of dimerization that is mediated by a tetrameric form of c-di-GMP.