Sentence examples for binding of a targeting from inspiring English sources
The rationale for combining two ligands was to counter weak binding of an activity element with stronger binding of a targeting element and to take advantage of a two-dimensional cell surface with both receptors embedded.
The binding of a target molecule is presumed to exert an effective local perturbation in the wire.
In some cases, binding of a target molecule or ligand drives disordered folding to a more ordered state [52].
In a first step one screens for mutations that affect binding of a target protein to its partners (B).
Pilot-scale studies are usually carried out to determine the binding of a target protein to a resin of interest and to determine the effect of different ionic concentrations and pH before scaling-up.
The most interesting aspect of adapting aptamers to act as biosensors or molecular probes is their structural flexibility, which means that binding of a target usually results in structural alteration or rearrangement of the aptamer [ 115, 116].
Upon binding of a target molecule, the proximity of the probes is disrupted, rendering the device fluorescent.[ 2, 3] Aptamer beacons have been generated via one of two general strategies.
In most cases, the net effect of miRISC binding to a target mRNA is a decrease in its protein levels.
The extent of 3WJdB and AF488-anti-tail delivered by Waz positively correlated with the levels of hTfR on target cancer cells measured with an anti-hTfR antibody (Supplementary Figs. 9 and 10), further confirming that the binding of a specific target receptor is responsible for the aptamer-mediated delivery of RNA payloads into target cells.
Interestingly, we were unable to detect binding of a dsDNA target sequence when dCas9 tracrRNA crXNA was immobilised on the SPR chip, possibly due to conformational restrictions imposed by immobilisation and covalent crosslinking.
The total free energy of binding of a microRNA-target pair was compared with the total free energy of binding of that microRNA with randomly shuffled versions of the mRNA 3'UTR sequence.
