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Based on the assumption that only a specific genetic variation would introduce certain biological events (e.g., binding of a special regulatory transcription factor may alter gene expression and drive disease pathogenesis), we identified 28 SNP-containing motifs in the selected gene group.
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Expression of the mecA results in production of a special penicillin-binding protein, PBP2a, which has reduced affinity to β-lactam antibiotics [ 1] and confers resistance to all practically used β-lactam antimicrobials.
This article is part of a Special Issue entitled RNA-Binding Proteins.
This article is part of a Special Issue entitled: Structural and biophysical characterisation of membrane protein ligand binding.
This article is part of a Special Issue entitled: Structural and biophysical characterization of membrane protein ligand binding.
This article is part of a Special Issue entitled: Structural and biophysical characterisation of membrane protein-ligand binding.
Think of a special edge.
Each time a form creates a lexical binding of a variable, a fresh binding is established.
This work demonstrates that using the competition of target protein with an ECL signal compound Ru bpy 32+ for binding sites of special aptamer confined on the electrode is promising approach for the design of label-free ECL aptasensors for the determination of proteins.
In order to minimize non-specific binding, CodeLink slides with a special coating were used.
Obviously, the described above stepwise binding mechanism, where intrinsic disorder of some proteins allows them to interact with hidden binding sites of ordered partners, represents a special case of a more general allosteric mechanism, where the complex formation between an IDP and its target leads to conformational changes in a target and opening of a hidden binding site.
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CEO of Professional Science Editing for Scientists @ prosciediting.com