Sentence examples for binding of a regulatory from inspiring English sources

This involves a conformation of the kinase active site that is unable to support catalysis and requires activation through a signal such as binding of a regulatory protein.

One of the strongest sources of stochasticity is the binary noise that arises from the binding of a regulatory protein to a promoter in the chromosomal DNA.

This transition was characterized as a reversible conformational change: binding of a regulatory effector molecule to the allosteric site modulates the protein activity at the functional site.

In summary, this step of our methodology aims to reliably predict binding of a regulatory protein to its targets under different experimental conditions.

Likewise, through the combination of single-molecule manipulation and single-molecule fluorescence methods in the same experiment, it should be possible to follow, for example, the internal dynamics of the polymerase or the binding of a regulatory factor and simultaneously monitor the mechanical variables of position, force, and torque.

At the same time, only a minority of known SNP markers are located in regulatory regions of genes because their experimental detection is complicated by the tissue- and developmental-stage-specific variation in binding of a regulatory protein to the these DNA regions [ 23, 25, 27, 30, 77].

Controlling enzyme activity by ligand binding to a regulatory domain of choice may have many applications e.g. as biosensors and as tools in regulating cellular functions.

The second model we tested is a prokaryotic auto-regulatory gene network in which dimmers of a protein repress its own gene transcription by binding to a regulatory region upstream of the gene.

The full specific activity towards a certain substrate of PP-2A core enzyme is achieved through binding of a variable regulatory subunit to form the heterotrimeric holoenzyme [6].

Based on the assumption that only a specific genetic variation would introduce certain biological events (e.g., binding of a special regulatory transcription factor may alter gene expression and drive disease pathogenesis), we identified 28 SNP-containing motifs in the selected gene group.

On the contrary, chelated MgADP (or MgATP) stimulates channel activity through specific interaction with the nt-binding domains of a regulatory subunit of the channel [(sulphonylurea receptor (SUR ], counteracting these nts' simultaneous inhibitory effect at the channel pore [ 7].