Sentence examples for binding of a particular from inspiring English sources

For the positively associated motifs that contain a CpG site, it may be the methylation of that specific CpG, which allows the binding of a particular TF that only binds to methylated DNA and promotes transcription.

In vitro studies show that aplaviroc selectively inhibits the binding of a particular monoclonal antibody, 45531, to CCR5.

In a process known as allosteric regulation, the binding of a particular small molecule changes the shape of the protein's catalytic site, allowing it to function.

Each of these rSNPs has previous empirical evidence to show that the nucleotide variation disrupts the binding of a particular TF.

For a given SNP V, we estimated its effect on the binding of a particular transcription factor tf, denoted by the matching score S tf (V), by evaluating the binding affinity differences between reference and alternative alleles; the binding affinity was calculated using the position weight matrices (PWMs) documented in the TRANSFAC database using previously published methods (Wang et al., 2008).

This observation raises the intriguing possibility that these sequences are specific for binding of a particular MAPK, or MAPK family, and that there is competition among MAPKs for binding, with the likelihood that a mechanism(s) exists for the regulation of this binding.

For example, ATF4 induces expression of its target gene C/EBP homology protein (CHOP) by binding to a particular type of CARE in its promoter, the Amino Acid Response Element (AARE) (9, 29, 30).

Histone chaperones generally show preferential binding to a particular class of histones.

For example, the ChIP protocol has been modified for the cloning and subsequent identification of transcription factor binding sites (4, 5) and for mapping binding sites of a particular protein on a genome wide scale in combination with microarray analysis (6- 10).

Under this assumption, the peptide binding affinity of each SH3 domain can be expressed as a 20×10 matrix where each element represents the binding energy of a particular amino acid at a specific position of the peptide.

Lastly, it is possible to design intrabodies to block certain binding interactions of a particular target molecule, while sparing others.