Sentence examples for binding of a nucleotide from inspiring English sources

Moreover, the catalytic activity may be enabled or suppressed upon binding of a nucleotide strand [16].

The loop of the empty active site recruits PurS by swinging out into the solvent, while binding of a nucleotide in the auxiliary site makes the docking of PurQ possible.

With regard to this point, a single-molecule study using a chimaera F1-ATPase showed that a certain reaction occurs at 320° after the binding of a nucleotide to F1-ATPase (Ariga et al, 2007).

Binding of a nucleotide results in a conformational change (repositioning of the N-subdomain of the polymerase domain) that provides the enzyme the opportunity to probe proper base pair geometry.

We therefore infer that an early event in the DNA polymerase reaction pathway, following the binding of any nucleotide to form a ternary complex, is the formation of a partially closed complex similar, but not necessarily identical, to the G-dTTP mispair structure.

Therefore, conditions suitable for discrimination of the nucleotides and for most efficient binding of a single nucleotide component can be selected.

Although highly successful in advancing our understanding of nucleotide binding and the origin of its cooperativity with Mg2+ ions, these studies lacked structural details and could not provide the precise contributions of individual groups to binding of a given nucleotide.

In growth factor signalling, the transition between the inactive and the activated state is engendered by the binding of a guanine nucleotide exchange factor (GEF) that displaces GDP.

With further binding of an incoming nucleotide, F146W and S229W show negligible changes because both mutants are away from the active site.

Once cells are exposed to conditions that are stressful or harmful, AMPK changes its conformation through the direct binding of an adenine nucleotide to the γ regulatory subunit and/or is activated through the phosphorylation of Thr172 of the catalytic α subunit by an upstream protein kinase (i.e., LKB1 or CaMKKβ) (Fig. 1).

GKPIDs and gk enzymes, however, have entirely different biochemical functions – specific protein binding and catalysis of a nucleotide substrate – suggesting the evolution of an entirely new function.