Baumgartner, R. et al. Dual binding mode of a novel series of DHODH inhibitors.
Baumgartner R, Walloschek M, Kralik M, Gotschlich A, Tasler S, Mies J, et al. Dual binding mode of a novel series of DHODH inhibitors.
Using a database of such affinity fingerprints, the authors were able to predict the binding potency of a novel compound for a specific protein target using a multivariate linear regression model, derived from the affinity fingerprints of a small set of training compounds.
These methods fall short when used to characterize the binding profile of a novel active site or one for which a template is not available.
Finally, detailed analysis of CTCF footprints suggests multiple modes of binding and a novel DNA binding motif upstream of the primary binding site.
Indeed, the difficulty that some unestablished novelists find in gaining a readership (which means the attention of a commercial publisher) has led them to take the copying machine as seriously as the printing press and to make the composition, mimeographing, binding, and distribution of a novel into a single cottage industry.
The Saccharomyces cerevisiae homolog of UBL5, Hub1, functions within a spliceosome complex with Snu66 and Prp8 (the yeast homolog of PRPF8), binding via a novel HIND interaction domain independent of the terminal dityrosine.
Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.
2DBD-NR can interact as a homodimer indicating that four P-boxes may be involved in DNA binding, thus a novel mechanism of DNA binding, which requires two independent pairs of half-site repeats, or four half-site repeats, each with unknown orientations and spacing, are predicted to exist to allow 2DBD-NR to bind to target DNA cis-elements.
Novick, D. et al. Interleukin-18 binding protein: a novel modulator of the Th1 cytokine response.
