Sentence examples for binding of a miRNA from inspiring English sources

The binding of a miRNA to this complementary sequence decreases translation of the target mRNA via several mechanisms, including mRNA degradation, inhibition of translational initiation and elongation (Eulalio et al., 2008; Filipowicz et al., 2008; Ameres and Zamore, 2013; Ha and Kim, 2014).

The most widely studied mechanism of regulation involves binding of a miRNA to the target mRNA.

It shows how strong the binding of a miRNA with its target is by predicting how the miRNA and its candidate target will hybridize.

Homologous binding of a miRNA to its target genes leads to mRNA degradation and translational inhibition but also induces DNA methylation [ 9- 14].

The binding of a miRNA leads to the degradation of the mRNA molecule or alternatively, to the suppression of mRNA translation, depending on the level of complementary binding 7. Because one miRNA can have multiple targets and one mRNA molecule can be targeted by many miRNAs, miRNAs form a complex level of regulation of gene expression.

Such target sites are typically located within the 3′ untranslated regions (3′ UTRs) of mRNAs, and binding of a miRNA to a target site predominantly causes the target's accelerated decay and resulting protein repression (Bartel 2009; Fabian et al. 2010; Guo et al. 2010; Eichhorn et al. 2014).

Here we describe a posttranscriptional pathway involving the binding of an miRNA to the 3′-untranslated region (3′-UTR) of the BAG3 gene, resulting in increased BAG3 expression.

The binding of an miRNA to an mRNA is not exclusive, as a single miRNA can target hundreds of mRNAs, and a single mRNA can be affected by multiple miRNAs (Selbach et al, 2008).

We then used TargetFinder [ 64] to identify putative binding sites of a miRNA on mRNA transcripts.

To further restrict the number of potential targets, the location of each binding site of a miRNA to a target gene was classified by location: 5'UTR, CDS, or 3'UTR.

The analysis of the gene expression data allowed identification of genes that were inversely co-expressed with a miRNA, whereas the target prediction was used to identify genes containing binding sites of a miRNA.