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The specific binding of a large pool of Gpx3 to basement membranes in the kidney cortex strongly suggests a need for glutathione peroxidase activity in the cortical peritubular space.
This would allow sufficient space to accommodate the binding of a large enzyme molecule.
Because of albumin binding of a large portion of PFCs in the blood, the glomerular filtration rate is low.
Platelets are deposited on damaged atherosclerotic plaques together with deposition of fibrin and thrombin and binding of a large protein called von Willebrand factor (vWf), collagen, and tissue factor, culminating in occlusive thrombus formation.
The binding of a large oleate molecule by van der Waals' interactions would be expected to be stronger than that of a butyrate.
The LBS-like sequence in the IL-22R1 promoter is located close to the transcription start site (−64 to −48), and the binding of a large protein like LANA may compete with other transcription factors to cause transcriptional repression.
Similar(49)
We found 7 highly activated transcription factors (TFs) [ argR, codY, hup, rpoD, rr02, scrR and smrC] capable of binding to a large number of up-regulated genes, potentially constituting the regulatory backbone of pneumococcal pathogenesis.
The 14-3-3epsilon 14-3-3epsilon 14-3-3epsilonbinding to a large number of other proteins is alsoosphorylation-dependent manner.
Our analysis showed that 7 TFs (argR, codY, hup, rpoD, rr02, scrR and smrC) were highly activated in all 3 strains in vivo and were capable of binding to a large number of up-regulated genes.
However the decrease in SH2 binding was blunted in H441 compared to H358 and HCC827, and the binding of a larger number of SH2 domains increased in the presence of both inhibitors compared to untreated cells.
As organisms evolve, the more complex interactome regulating DNA replication, repair, and cell cycle control may require a higher tolerance by PCNA to accommodate the binding of a larger variety of PCNA ligands, presenting more diverse PIP sequences.
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