The content of this database comprises information about the biological components of the endocrine system, like hormones, receptors and cells, as well as their relations like the secretion or the binding of a hormone to its receptor.
PLC is activated by binding of a hormone or growth factor to its receptor and PLC in turn converts phosphatidylinositol-4,5-bisphosphate into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol.
Such stimuli can, for example, consist of the binding of a hormone to cellular surface receptors and may initiate a series of reactions inside the cell, eventually leading to a change of cell state, directed movement, its proliferation or death.
Ca2+ Signals are generally initiated by the binding of a hormone or growth factor to a transmembrane receptor, most commonly G protein coupled receptor (GPR) or tyrosine kinase receptor (RTK).
Molecular studies disclose details of the endocrine system, like the expression of a receptor in a specific tissue, the binding of a hormone to a receptor, or the molecular effect of a receptor's activation.
We assume that binding of a hormone or an inhibitor by an ER monomer can affect ER dimerisation, that may result in differences in kinetic constants assigned to stages 1, 5, 6, 10, 11 and 12.
We verified the hypothesis experimentally and identified four amino acids which are to a different degree required for ligand-binding of a plant hormone receptor.
HREs bind nuclear hormone receptors that act as ligand-induced transcription factors following the binding of an appropriate steroid, hormone or vitamin, activating or suppressing gene transcription [ 97].
The binding of the hormone induces a change in the dimeric structure of the receptors, and this removes the inhibitory action.
According to this, the activation mechanism of GPHRs can be defined by the following independent steps: binding of the hormone or an agonist stimulating antibody to the LRD of the receptor's ECD; activation of the ECD of the receptor; signal transduction from the ECD to the TMD; activation of the TMD; and activation of the G protein.
Biochemical receptors are large protein molecules that can be activated by the binding of a ligand (such as a hormone or drug).
