Sentence examples for binding of a given from inspiring English sources

The findings show how the binding of a given ligand to its site leads to conformational and functional changes throughout the GABAA receptor, including changes to the binding sites of other ligands.

The proposed mode of action is that selective binding of a given sFasL fusion protein results in its accretion at the cell surface of T-cells only, displaying a surplus of sFasL that is available to reactivate AICD in pathogenic synovial T-cells.

In principal, the probability of occurrence of a gene transcription event is given by the probability of binding of a given transcription factor molecule to the promoter region of a gene.

Several models of muscle contraction assume that only one binding site on the actin filament is within reach for binding of a given myosin head.

In most cases, the contribution of the individual amino acids towards the binding of a given ligand is not well understood.

It is therefore possible that phosphorylation of either of these sites could affect a net charge value and have impact on binding of a given cargo.

In addition, the absence of binding to a given peptide may provide data on inhibitory effects of specific residues.

CoMFA first aligns the ligands capable of binding to a given target, and then measure field intensities around the aligned ligands by different atom probes (force field-based).

This typically means that no small molecule (≤800 Da) has been found that is capable of binding to a given site with sufficient potency (typically KD ≪ 10 μM) and that elicits a biological response.

Nevertheless, it is highly probable that the observed variations of C10.36-dependent C10.36-dependent a given set of cells (Fig. 2 and Supplementary Fig. 6) may reflect differences in the expression of this unknown target.

Taken together, the simplicity of the motif and the rapid evolution of disordered regions drive a system where peptides complementary to the binding pocket of a given SLiM-binding domain are rapidly being created, by ex nihilo motif birth, and destroyed.