Sentence examples for binding of a fatty from inspiring English sources

Our aim here is to characterize binding of a fatty acid to KcsA.

Here we show that the fluorescent fatty acid Dauda can be used to characterize the binding of a fatty acid to the cavity in KcsA.

They have shown that binding of a fatty acid molecule to one subunit of COX induces a conformational change that alters the capacity of the second subunit to catalyze the oxygenation reaction.

(1277) Binding of a fatty acid changes the polarity and volume of the drug site I. (1290) These facts, along with the pH-dependent transitions, underline the difficulty of the HSA binding predictions under physiologic conditions.

Although we could force this increase in LA binding, we did not observe an increase in binding of a related fatty acid (palmitoleic acid, PLA, C16:1) provided under similar conditions (Figure 1C, bottom).

Removing the arginine 47/lysine 51 carboxylate binding motif at the mouth of the active site disfavours binding of all fatty acids, indicating its importance in the initial recognition of substrates.

The quenching data fit to a competitive binding model in which binding of a molecule of fatty acid displaced a molecule of DOPC from the site; an iterative fit of the two sets of data to the competitive binding model (eqs 4 and 5) gave values for n and the relative association constant K1 of 0.91 ± 0.24 and 0.87 ± 0.08, respectively.

A key residue in binding of polyunsaturated fatty acids and other hydrophobic molecules to IKCa1 is Val-275, equivalent to Ile-100 in KcsA, and the corresponding residue in Kv1.1, Val-505, has also been shown to be important in fatty acid binding.

Binding of the flavonoid to MtbHadAB can physically occlude binding of the fatty acid into the substrate binding channel (Fig. 6A).

Therefore, the flavonoids can scuttle binding of the fatty acid or prevent it from binding in a catalytically competent orientation.

Once microalbuminuria appears, binding of fatty acids to albumin may trigger fatty acid overload in the proximal tubules, and the L-FABP gene may, as a consequence, be upregulated to increase the free fatty acid transport into the mitochondria.