Sentence examples for binding of a drug from inspiring English sources

The degree of binding of a drug to a receptor can be measured directly by the use of radioactively labeled drugs or inferred indirectly from measurements of the biological effects of agonists and antagonists.

However, in occupancy studies, this is a challenging task where competitive binding of a drug can further reduce the available signal for registration.

Numerous different mechanisms have been proposed, varying from direct inhibition of the breakdown of phospholipids to the binding of a drug compound to the phospholipid, preventing breakdown.

The binding of a drug to a G-protein coupled receptor initiates a complex series of dynamic events that ultimately leads to a cellular response.

The binding of a drug to plasma protein reduces free drug in the blood circulation that would otherwise be available for penetration into tissues to reach the therapeutic target or the kidney for elimination.

Targeting this site may therefore not inhibit the enzyme, although the possibility of long range conformational changes induced by the binding of a drug cannot be ruled out.

Virtual screening (VS) is a reliable, inexpensive method for identifying leads by providing the screening of whole libraries of small molecules in order to get practically achievable number of compounds with the structures of the highest probability of binding to a drug target [53].

Druggable proteins should have a pocket with suitable features that enable binding of a drug-like compound (11, 15, 16).

Druggable proteins should have a pocket with suitable features that enable binding of a drug-like compound.

Advantageous physicochemical properties for drug binding can be estimated for any disease-relevant protein: simply put, the presence of a deep hydrophobic pocket that is large enough to allow for high-affinity binding of a drug-like molecule, in turn, able to modulate the target's "activity" [ 57].

Consideration of binding competitiveness of a drug candidate against natural ligands and other drugs that bind to the same receptor site may facilitate the rational development of a candidate into a potent drug.