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Importantly, genetic diversity in the ABS facilitates binding of a diverse array of antigens to the molecule [ 20].
Ubiquitin is an important signaling molecule involved in a myriad of signaling pathways through the binding of a diverse set of receptors.
In particular, the ABS sites display more non-synonymous than synonymous substitutions that change the amino acid sequence of the peptide and thus allow binding of a diverse array of antigens [ 19].
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The understanding of how small molecules can modulate the function of this important class of receptors by binding to a diverse range of pockets on and inside the proteins has had a profound impact on the structure-based drug design (SBDD) of new classes of therapeutic agents.
Raha and Merz used semi-empirical QM based scoring function for predicting binding energy and binding mode of a diverse set of protein-ligand complexes [22].
Although the functional significance of most of these sites remains to be assessed, regulation by E2F upon binding to a diverse group of sequences, such as 5'-GGGCGGGC-3' and 5'-GCTCCAAA-3', has been demonstrated for the ASK-1, and the carboxylesterase gene promoters, respectively [8], [9], [10].
P. falciparum IEs have been shown to have the potential for binding to a diverse array of endothelial receptors (Table 1).
In addition to its lymphangiogenic role, COX-2-upregulated VEGF-C directly promoted breast cancer cell motility, a phenotype for metastasis, by binding to a diverse group of VEGF-C receptors.
We were unable to identify a group of food-allergic people with markedly different outcomes, however previous work has identified that those with asthma, previous severe reaction, IgE binding to a diverse range of epitopes, deficient platelet-activating factor acetyl-hydrolase or serum angiotensin-converting enzyme may have more severe food-allergic reactions [ 28– 30].
Why has BAG2 evolved to specifically bind mutant p53 and how can it discriminate between the DNA binding domains of a diverse range of mutant p53 s compared to wild type?
The scoring function predicts binding energies of a diverse set of protein ligand complexes used for training with a correlation coefficient of 0.61.
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