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It is possible that the binding specificities of some of the CSBPs are altered over the cell cycle, or that weaker binding of this suboptimal CS is mechanistically important, e.g. allowing binding competition or synergy to occur between multiple CSBPs, or binding of a divergent CSBP.
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This type of regulator is consisted of a highly-conservative DNA-binding domain and a divergent acyl-CoA ligand-binding motif (Fig. 1).
First, TFs tend to exert stronger regulatory effects on the gene proximal to their binding sites in a divergent pair.
A complication is that many RNAs that are antisense to ribosome-binding regions could equally be the 5′ UTR of a divergent protein-coding gene.
Atlantic salmon TR-α exhibited the classic modular structure associated with members of the nuclear receptor superfamily and consisted of a divergent A/B domain while the DNA and ligand-binding domains were highly conserved to other teleost TR proteins.
The seven putative diatom class C GPCR sequences that contained the PBP1 ligand binding domain grouped within a divergent clade.
The assumption underlying the prediction of these SDRs was that these residues would be more conserved among orthologs, which are assumed to have a similar binding spectrum, than among paralogs, which are assumed to have a divergent binding spectrum.
In summary, STAT3 is capable of binding to widely divergent sites in distinct cell types, as well as to a small core of evolutionarily conserved sites in all cell types that regulates its own signalling.
An example of this is the decapping enzyme subunit Dcp1p, which contains a divergent variant of the peptide-binding EVH1 domain [ 54] that appears to have been recruited for a different, possibly catalytic function in the decapping process.
Therefore, HCF101 may represent a divergent type of Fe/S cluster-binding protein, which presumably evolved as an adaptation to oxygen evolution in the chloroplast.
Literature, like the politics of a Franklin Roosevelt, requires a divergent mind.
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CEO of Professional Science Editing for Scientists @ prosciediting.com