Sentence examples for binding of a compound from inspiring English sources

Researchers can only use dead cells or pieces of a cell and can only test for one response at a time, such as enzyme activity or the binding of a compound to a receptor.

Because the bias towards larger ligands is counter to the rules for drug bioavailability, [54] a simple metric, called ligand efficiency has been developed to assess the binding of a compound, with respect to the number of atoms, and its potential for lead optimisation [53, 55].

The binding of a compound with plasma proteins may also interfere with its inhibitory activity.

(5) These suppressor mutation results suggested that direct binding of a compound to the TMDs may promote the maturation and stability of ΔF508 CFTR.

The strategy of pharmaceutical research, defined as the specific binding of a compound to two or more molecular targets, has variously been termed "network-based" discovery, "multi-targeted" drug design, "targeted polypharmacology", or "polypharmacology" [ 9- 17].

The qHTS assays used at the NCGC focus on cell-based phenotypic or transactivation end points and do not measure directly the binding of a compound to a receptor or other cellular component.

Further, we have analyzed the molecular interactions of P-gp substrates/inhibitors during the P-gp translocation to find out how stable binding interactions of a compound at drug-binding site(s) in open conformation, becomes highly destabilized in closed conformation.

And the binding affinity of a compound to a protein in the pathway network was assessed by molecular docking.

Do the observed complexes occur in reality and is there a relationship between the docking score and the binding affinity of a compound?

The heat map visualization can be combined with structure based modeling approaches to gain a better understanding of the binding mode of a compound and therefore help medicinal chemists in lead optimization.

Together these results suggest that the binding affinity of a compound to PXR can be differentially affected by different modifications.