The RGG box is typically associated with binding to single-stranded nucleic acids, (Zhang and Grosse, 1997) whereas additional RNA-binding motifs may allow binding of a broader range of RNA targets as is the case for nucleolin (#33, Table S1) (Ghisolfi et al. 1992).
pK i values were determined by radioligand binding to a broad panel of receptors, channels and transporters at CEREP (Paris, France) [43] aActivity was tested against the following related TRP channels: rTRPV2, hTRPV4, hTRPA1, cTRPM8.
Already before treatment, there was robust antibody binding to a broad range of staphylococcal antigens.
The finding that 75% of the patients in the intermediate dose group developed a T-cell response to the vaccine supports the notion that GV1001 contains binding motifs that allows promiscuous binding to a broad array of HLA class II molecules.
All aptamers were characterized under identical conditions (10 mM HEPES, 150 mM NaCl, and 5 mM MgCl2 at pH 7.4 and 25 °C), enabling the first direct comparison of the binding properties of a broad set of small molecule-binding aptamers.
In order to provide coverage against a large variety of potential antigens, the B cell-encoded antibody repertoire is incredibly diverse, estimated to comprise >10 immunoglobulins with distinct variable domain sequences in human serum, resulting in an antibody population capable of binding a broad range of antigens with high affinity and specificity.
To be effective, any treaty should be legally binding and cover a broad range of weapons, including ammunition.
TFs bind to a broad spectrum of binding sites with different affinity and change targets widely among species.
While this brief scanning by the TR may provide an explanation for the feeble TR/pMHC interactions alluded to earlier, it becomes increasingly important to understand the minute aspects of this vital binding over a broad spectrum of data.
Such an interface formed by several interaction clusters/hot spots of binding allows for a broad range of affinities by selecting how many of these interaction clusters contribute to the overall binding free energy.
