Sentence examples for binding of Lig proteins from inspiring English sources

This suggests the pivotal role of 13th Ig-like domain of LigA and 12th Ig-like domain of LigB for the binding of Lig proteins to GBD.

As shown in Figure 4A and B, the more Ig-like domains included in the Lig constructs, the greater the binding of Lig proteins to MDCK cells.

Answering this question is necessary to understand the Ca2+-binding features of Lig proteins, which would eventually help in elucidating their role in the Ca2+ dependency of pathophysiology of leptospirosis.

Since many Ca2+-binding proteins also bind Mg2+, we examined Mg2+ binding to these domains of Lig proteins.

On the other hand, the comparably weaker KD and smaller kon of GBD and Ig-like domains of LigA or LigB compared to other Fn binding proteins indicates a possible role of Lig proteins in transmission of Leptospira [37], [38], and this phenomenon was also discovered in the NTD binding region of LigB, LigBCen2NR [13].

More studies are required to understand the molecular nature of Ca2+-binding to these proteins though interaction of Lig proteins with extracellular matrix proteins is enhanced in the presence of Ca2+, thus implicating the Ca2+-protein interaction in pathophysiology and virulence [17].

The ability of Lig proteins to inhibit binding was also significantly increased when the constructs included the last Ig-like domains (Figure 4C and D).

In order to investigate the effect of the number of Ig-like domains of Lig proteins on GBD binding, the truncated proteins of each construct of the variable regions of LigA and LigB were purified.

It is not known if Big domains of Lig proteins bind Ca2+.

We have investigated whether individual Big repeats of Lig proteins bind Ca2+ and compared the spectral features of selected individual domains.

To understand if any Big fold of Lig proteins would bind Ca2+, we selected several repeats to assay for Ca2+-binding (Figure 1A).