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Our data also demonstrate that the N-terminal region of HIV-1 Vif mediates its binding not only to the target molecules A3G and A3F but also to A3C and A3DE.
Consistently, ChIP of endogenous YAP and TEAD1 showed binding not only to CTGF promoter as previously reported, but also to miR-130a promoter.
Here, the glycosylations are found to participate significantly in TrCel7A binding not only to cellulose, but also to lignin and other TrCel7A molecules (Table 1).
The VEGF inhibitor selected was aflibercept, due to its binding not only to the VEGF-A isomers (like bevacizumab and ranibizumab), but also to VEGF-B and placental growth factor [ 26].
In this way, we could test binding not only to mCG, but also to methyl-CA (mCA) and hydroxymethyl-CA (hmCA), which are all implicated as target sequences for MeCP2 (27).
Although Ku80 did not bind any of the studied promoters (data not shown), unexpectedly, our ChIP experiment demonstrated PARP1 binding not only to the HSP70 promoter, but to all promoters tested, with the highest level of bound PARP1 protein at the HBB promoter (Fig. 6A and B).
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Both hSHA and hLHA exhibited binding abilities; however, hLHA-displaying yeasts would be more useful in inhibitor screening assays since it is more likely that inhibitors would bind not only to the binding site but also to the stem region.
These structural modifications affect the affinity of the TTR-binding site not only to T4 but also to exogenous compounds, and explain the differences in the TTR-binding potency of compounds reported between species.
It therefore has some similar roles to its bacterial counterpart, where Era binding not only protects the 16S rRNA precursor, it also binds in a pocket that precludes the 50S subunit from associating with the 30S subunit.
Thus, the orientation was similar to membrane-bound lipidated N-Ras.[ 26] This indicates that in this case, the artificial binding not only immobilized the protein efficiently but even mimicked the natural anchor to a certain degree.
He instituted a law (Lex Hortensia) making plebiscita (measures passed in the plebeian assembly) binding not only on plebeians but also on the rest of the community.
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