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It therefore has some similar roles to its bacterial counterpart, where Era binding not only protects the 16S rRNA precursor, it also binds in a pocket that precludes the 50S subunit from associating with the 30S subunit.
Inhibitor binding not only stabilized the substrate binding loop but also revealed that the substrate binding tunnel has an overall shape of "U".
He instituted a law (Lex Hortensia) making plebiscita (measures passed in the plebeian assembly) binding not only on plebeians but also on the rest of the community.
By contrast, immunizations with the entire SAF61 mAb generated anti-Id antibodies specifically competing with soluble or membrane-bound hPrP (in EIA or flow cytometry experiments, respectively) for binding not only SAF61 mAb but also other anti-PrP mAbs directed against similar epitopes, i.e. behaving as "internal images" of this disease-related PrP epitope.
Thus, ligand binding not only determines the direction but also the extent of the conformational change.
Indeed, the compound prevented MT binding not only of the Ndc80 complex but also of the MT plus-end tracking CLIP-170 protein, suggesting that it acted specifically towards the MTs.
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By scanning binding pockets, not only the ligand binding sites of a given protein can be identified, but also protein residues within a suitable range of the binding pocket are identified, which could be used for analysis of functional sites and comparison.
Another main feature of STAP is the utility of genome-wide binding data not only as binary indicators of TF binding regions, as been done by most existing studies, but also as quantitative measurements of the binding strengths.
High-affinity binding was not only detected for mAb HO-3, but also for the monovalent EpCAM-binding arm of catumaxomab with an excellent KD of 5.6 × 10−10 M.
The heat changes upon ligand binding do not only yield information on the dissociation constant (and thus ΔG) and the number of binding sites, but also on the enthalpy (ΔH) and entropy (ΔS) changes.
Biotinylated Mut or Del LoNA pulldown assays revealed that both Mut and Del LoNA variants exhibited extremely weak binding affinities not only to FBL, but also to other components of snoRNP complex, as compared to WT LoNA (Fig. 4e), indicating that LoNA binds to FBL primarily through its box C/D structures.
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