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Antigenic similarity of the LOS to oligomannose was evidenced by 2G12 binding to the LOS and the inability of sera elicited against synthetic oligomannosides, but incapable of binding natural oligomannose, to bind the LOS.
Biocomposites are typically formed by binding natural fibers derived from plants or cellulose using organic binders.
We therefore postulate that the hemadsorption site of influenza virus NA serves to enhance the catalytic efficiency of the NA by binding natural multivalent substrates and thus recruiting and keeping them in the vicinity of the enzymatic site.
A few crystal structures do not belong to one of these subsets, since their additional ligands are not TR (e.g. antibody pMH binding, natural killer cell receptor pMH binding, etc).
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Meridamycin is a non-immunosuppressive, FKBP12-binding natural macrolide with potential therapeutic applications in a variety of medical conditions.
Pironetin is an α-tubulin-binding natural product with potent antiproliferative activity against several cancer cell lines that inhibits cell division by forming a covalent adduct with α-tubulin via a Michael addition into the natural product's α,β-unsaturated lactone.
Methanobactins (Mbns) are a family of copper-binding natural products involved in copper uptake by methanotrophic bacteria.
Results In this study, the authors tested the effects of a neuron-binding natural human monoclonal IgM, rHIgM12, on two superoxide dismutase-1 (SOD1 )-mutant mouse strains, two well-known models of ALS.
Due to the mutation of the LBD, only the synthetic ligand can bind, thereby circumventing binding of natural ligands that activate the construct.
Nuclear receptor activity is controlled by the binding of natural small molecules or ligands including hormones and metabolites and many synthetic compounds have been designed to mimic these natural regulators [ 2].
On a recent afternoon, LaVar was tightly binding the natural hair of a middle-aged, heavily made-up white woman to the top of her head in a grid pattern and using a long, crescent-shaped hook to sew wefts--essentially, bands o fhuman hair that resemble miniature hula skirts--onto the grid.
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