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A typographic error for the YXXΦ binding mutant is present in previous publications (Honing et al., 2005; Edeling et al., 2006; Motley et al., 2006).
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We found that although the WT and the ΔWR TWIST1 mutant were associated with the IL8 promoter, the S144R/K145E DNA binding mutant is not presented at the same region, confirming that these point mutations indeed disrupt the DNA binding ability of the protein.
Unlike autosomal recessive diseases, autosomal dominant diseases are expressed when only one mutant gene is present.
When mutant huntingtin is present, however, far too many cells induce apoptosis.
If normal or mutant CD22 pre-mRNA is present in the cell, the RTM binding domain can base-pair with its complementary region in CD22 intron 9.
Twelve binding sites are present within the dodecameric channel.
All Cys/Ala mutants except those whose Cys is present within ZZ domain showed normal binding to Nt-Arg (Fig. 2f).
The p.R814X mutant lacks the BRCT 2 motif, but the NLS and XRCC4-binding site are present [Ben-Omran et al., 2005; O'Driscoll, et al., 2001].
When dopamine and mutant huntingtin are present together, the level of c-jun is greatly increased.
Last year, Dr. Klar said, geneticists identified a gene that is present in normal mice but totally missing in the mutants.
No legally binding treaties were presented or signed.
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