Sentence examples for binding motifs were enriched from inspiring English sources
Unlike the direct targets of E2, both the direct targets of MYC in B-cell lymphoma and genes containing MYC binding motifs were enriched in ER− tumors.
Similar Hairy binding motifs were enriched in both data sets, indicating that the induced Hairy protein has similar targeting specificity to the endogenous protein.
The use of resampling methodology in uncovering the enriched binding motifs revealed that most of the 58 transcription factors would probably not generalize well in other data sets because their binding motifs were enriched in only small portion of the resampled sample sets.
Interestingly, the DHSs with OCT4 binding motifs are enriched at the timing of zygotic genome activation (ZGA) in humans, but not in mice.
(A ) Adipogenic TF binding motifs are enriched at MLL4 binding regions during adipogenesis while myogenic TF binding motifs are enriched at MLL4 binding regions in myocytes.
This mirrors a finding by Smith et al. [ 36], where they showed that ELK1 binding motifs are enriched in the promoters of genes also bound by HNF4α.
and results on typical data-related research questions, for instance which genes are differentially expressed or differentially spliced, which genomic variations are unique to a sample compared to a control, which transcription factor binding motifs are enriched in a ChIP-Seq data set etc. The results and report are generated fully automatically without any additional user action.
Interestingly, the ABRE and ABRE-like binding motif were enriched in the 2nd and 3rd clusters (both within the first 0.5 kb and 1 kb).
MEF2A and E4BP4 DNA-binding motifs were enriched among FSHD-downregulated genes, which is consistent with the downregulation of MEF2A RNA in FSHD vs. control myotubes and its role in myogenesis and the role of E4BP4/NFIL3 as a transcription repressor.
Zeller et al. [33] found the E2F1 binding motif is enriched 16-fold in clusters of MYC-binding genes, and 37-fold within the subset of E-box containing genes.
