It has four potential PTB-binding motifs that interact with the α-helical face of RRM2 (Rideau et al, 2006), and it was possible that it could facilitate the formation of extended complexes.
The last few residues (with the sequence NAV) of the C-terminal domain of SERT have been proposed to adopt a noncanonical PDZ binding motif that may interact with nNOS.
The W-box is a binding motif that has been identified in WRKY transcription factors.
At the end of this carboxy terminus there is usually a PDZ domain-binding motif that can interact with PDZ domains of TJ scaffolding/adapter proteins including ZO-1, ZO-2 and ZO-3 [ 59, 60].
SALMs 1 3 contain an extracellular region consisting of a leucine-rich repeat (LRR), a fibronectin type III domain, Ig-like domains, a transmembrane domain, and a C-terminal PDZ-binding motif that interacts with PSD-95.
In addition to its GEF domain, Map contains a C-terminal PDZ domain-binding motif that interacts with EBP50, and both domains are required to polarize Cdc42 activity on the cell membrane.
SAFB1 has a RNA binding domain [ 21], a nuclear localisation domain, Glu/Arg, Ser/Lys, and Gly rich protein interactions regions and a SAF-Box, which is a homeodomain-like DNA-binding motif that interacts with AT-rich scaffold-matrix attachment regions (S/MARs) [ 22, 23].
However they do not exhibit any apparent nucleotide-dependent dynamics, and while guanine nucleotide binding promotes septin stability, hydrolysis is not needed in vivo., A unique property of septins is that they contain a lipid-binding motif that allows them to interact directly with membranes.
Structure-function details of different Cldns are only beginning to emerge, but the COOH-terminal tail varies considerably in length and is the region with the most sequence heterogeneity among Cldn isoforms, and in most cases contains a PDZ-binding motif that enables Cldns to directly interact with the TJ-associated MAGUKs (ZO-1, ZO-2, and ZO-3) as well as with MUPP1 and PATJ [35] [38].
Our data cannot distinguish whether Ubiquitin binds separately to the VHS and to the UIM (two Ubiquitins bound per STAM2) or if the two binding motifs interact cooperatively to increase the overall affinity of Ubiquitin over that of the binding to either motif separately.
