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For instance, the LTR-derived promoter significantly increases the expression of human EBR gene in placenta (Medstrand et al. 2001), and Alu elements provide binding motifs for three zinc-finger TFs (Sp1, estrogen receptor alpha, and YY1) (Oei et al. 2004).
The high proportion of RBPs in the expression profiles and the high percentage of transcripts containing binding motifs for three prominent RBPs in their downstream sequences suggest an important role for RNA binding in vascular tissue.
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For example, in mESC ChIP-seq data for the TF Esrrb, we discover the binding motifs for eight cofactor TFs important in the maintenance of pluripotency.
Therefore, we compared the amino acid sequences of these two MHC class I molecules to determine whether we could predict a peptide binding motif for Mamu-B*08 extrapolated from the known motif of Mamu-B*03 [75].
At the same time, a preliminary binding motif for Mamu-B*08, defined on the basis of structural analyses, is similar to that defined for HLA-B27 [75], [79], [80], [80].
Finally, we proceeded to predict de novo DNA-binding motifs for twenty TFs with previously uncharacterized binding motifs.
PDZ domains well represent protein binding motifs for which four high-resolution structures of distantly related members exist [25], [29], [30].
We identified candidate binding motifs for all ten EBPs upstream of the respective orthologous σ-dependent promoters.
As expected from previous multi-species ChIP study of CEBPA and HNF4A (Schmidt et al., 2010), the known binding motifs for the four TFs was virtually identical between species and occurred close to the ChIP-seq binding summit.
We next investigated whether the predicted nuclear receptor binding sites are necessary for CRM activity by mutating the predicted binding motifs for NR in two enhancers, CG17298 and CG4998.
Furthermore, CisFinder identified several alternative binding motifs for CTCF (b e), including three palindromes (b d).
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