Sentence examples for binding motif was present from inspiring English sources
The promoter analysis of TP53 binding genes resulted in the top ranking E-score (~3.3) but not the top ranking P-score for TP53 (Additional file 1, Figure S1C) even though the TP53 binding motif was present in 71% of the promoters (Additional file 1, Figure S1D).
To determine whether the AHR binding motif was present in the promoters of the genes coding for these factors, we used the TRANSFAC algorithm (Wingender 2008) to search for the presence of AHR position weight matrix motifs anywhere between –10,000 and +1,000 nucleotides from the transcription start site.
Thus, the aspartic acid 84 glutamic acid 85 alanine 86–valine 87 (DEAV) peptide binding motif was present in 20 (64%) of the 31 DP alleles in the current patient series, while the remainder had either glycine 84 glycine 85–proline 86–methionine 87 (GGPM) in 10 (32%) alleles, or valine 84 glycine 85–proline 86–methionine 87 (VGPM) in one (3%) DP allele (DPB1*1501).
Closer inspection of these binding sites revealed that 3420 83.7%%) of the non-CTCF bound binding sites contained the CTCF motif, indicating that they are either not bound by CTCF in ESCs, even though the binding motif is present or that these sites were not detected during ChIP-sequencing.
Additionally, the SOX9 binding motif is present in the proximal promoter of the TRPS1 gene according to the prior knowledge.
Through a systematic sequence-based analysis, we found that a conserved filamin binding motif is present in the cytoplasmic domains of >20% of the 824 GPCRs encoded in the human genome.
In a previous study, we defined the fine specificity of anti-CENP-A Ab and discovered that one of the two identified binding motifs was present not only in CENP-A but also in FOXE3, a protein not previously implicated in SSc [ 18].
Because the UCRs are much longer than usual protein binding motifs, it is possible that multiple binding motifs are present in a single UCR.
Low affinity binding motifs are present in endocytic proteins [103] and it has been suggested that low affinity protein-protein interactions are essential for the rapid and accurate coordination between the vast range of components involved in membrane trafficking pathways such as endocytosis [104,105].
