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Another TF binding motif that is active in the neuronal lineage is Nrsf/Rest.
Each MHC class I molecule, whose total number surpasses the thousands of alleles to date [5], is characterized by a specific binding motif that is possible to "decode".
From the bioinformatic analyses, we had identified a second candidate TCF binding motif that is conserved in human, chimpanzee and dog (Fig. 1, position indicated by asterisk).
PKCε contains an actin binding motif that is unique to this individual member of the PKC family [37] suggesting that this isozyme may be playing a role in this context.
TCTEX1D4 has a PPP1 binding motif that is evolutionarily conserved among species (Fig. 2).
Not surprisingly, it is almost only the homeodomain, which serves as sequence-specific DNA binding motif that is conserved amongst different species [ 46].
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The DNA binding motif that was identified in L. lactis IL1403 resembles CodY-TFBS[MG1363] CodY-TFBS[MG1363]-TFBS[IL1403] reported by Guedon et al. [ 68].
A second DNA binding motif that was overrepresented (p = 1.6E -5) in NKX3.1 responsive genes conforms to a binding site for serum response factor (SRF). 216 human genes contain the serum response element (SRE) motif in a promoter proximal context that is conserved in mouse, rat, and dog.
The structure reveals an unusual double-stranded RNA binding domain (dsRBD) fold embedding a novel zinc-binding motif that is conserved among dicers in yeast.
Sequence analysis of these genes reveals that all except HiGH61G possess the conserved metal-binding motif that is essential for activity (Fig. 1).
Because ADAM11 does not have the zinc-binding motif that is required for metalloproteinase activity, it is conceivable that part of the ADAM11 propeptide may have been lost in frogs during evolution.
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