Sentence examples for binding motif required for from inspiring English sources
From the docking of twenty-seven analoguessine analogues, a 3-point inhibitor binding motif required for activity was established and successfully utilised in the development of a tripeptide displaying an EC50 value of 10 ± 5 μM in HIV infected human T-cells.
However, the definitive characteristics of the CTCF binding motif required for its functional diversity still remains elusive.
Specifically, these types of cofactors might discern differences in the number and type of transcription factor binding motifs required for NF-κB itself, as well as for the putative cofactors.
This study aimed to decipher the mechanics of p63 binding by determining the minimal in-vivo motif required for binding, distinguishing between chromatin architecture of bound and unbound motifs and identifying cooperating TFs that modulate p63 biological activity.
Through single amino acid substitutions of the phage-displayed peptide sequence, it was possible to identify the minimal essential motif required for binding to RMS cells as Arg-X(Arg/Lys)(Arg/Lys): lysines and arginines were interchangeable without loss of affinity towards RMS cells.
This arginine is in the FLVR motif required for binding to phosphotyrosines [ 54, 55].
Like other co-regulators, this REA protein contains the LXXLL motif required for binding to steroid receptors and it inhibits oestradiol-ER complex activity on several different oestrogen responsive promoters.
A degenerate motif, the so-called RVxF motif found on many targeting subunits, is an essential interaction motif required for PP1c binding and regulation (Egloff et al. 1997).
Moreover, the DISC1 arginine-rich motif required for TRAK1 binding is conserved in mouse, apart from a conservative substitution of glutamine for the first arginine (27).
Interaction with actin filaments is mediated by the EVH2 sequence, which contains an actin binding domain (BD) and a tetramerization motif required for polymerase activity.
However, the PPXY motif required for YAP binding present on the longer isoforms of p73 is also conserved on ΔNp63 α.
