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We refer to this region as the SH3 binding motif rather than the proline-rich region due to the conservation of the motif across taxa although the area surrounding the motif is not necessarily proline-rich in some nematode taxa.
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Two open reading frames in the mouse genome show rather low similarity to the CDO sequence but have the key cupin metal binding motif rather well conserved.
In conclusion, we first characterised a stefin-type inhibitor which in addition to the regular papain-binding motif rather surprisingly contains a legumain-binding domain and thus effectively inhibits asparaginyl endopeptidases.
Although the exact protein binding sites on minHOTAIR remain to be elucidated, these well-defined footprinting patterns we have observed indicate that EZH2-EED binding to minHOTAIR is likely to be mediated by a specific RNA motif, rather than the result of binding by nonspecific interactions.
Along those lines we have begun developing related algorithms which are designed to learn the actual binding site motifs rather than simply make a prediction of "positive" or "negative" (Kon et al. 2007.
These results indicated that CPP ecp containing core RWRCK motif, rather than containing known heparin-binding motif, inhibited CT-26 cell migration across the membrane in vitro.
But the designer had another motif rather than just mere decoration.
In bacteria, the W motif, rather than the R.Y motif, was found to be the predominating binary motif [ 15, 16].
Moreover, the matched fragment had to include a conserved motif rather than a random match.
We conclude that both GH-induced GHR endocytosis and constitutive GHR endocytosis depend on βTrCP binding via the UbE-motif rather than via the DSGxxS motif.
Interestingly, Abd-B motifs, rather than Ubx motifs, show the highest enrichment.
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