Sentence examples for binding motif of an from inspiring English sources

This sequence is almost identical to the known binding motif of an E. coli global transcriptional factor Crp (AAA TGTGATCTAGA TCACA TTT) [ 39].

We thus assume that the core binding motif of a TF of interest has been determined a priori and is provided as an input to TRANSMODIS.

Two inverted AGAA-boxes in the xyn2 promoter were previously considered to be the binding motif of a repressor [ 21, 22].

For example, a single nucleotide variant (SNV) may hit the binding motif of a transcription factor, which affects the proper binding of it and leads to an expression level change of the regulated gene.

These results suggest that phosphorylation of the PDZ binding motif of a target protein might not affect association with the PDZ domain but can still play a role in the functioning of its target protein.

For prior knowledge source 3, we added a potential interaction if the respective binding motif of a transcription factor occurred in the regulatory region of genes included in the model.

In order to choose an appropriate peak threshold, we followed the guidelines of the ENCODE consortium [ 35], which require that a known binding motif of a transcription factor should be at least four-fold enriched and occur in at least 10% of the peak regions extracted from corresponding ChIP-Seq data.

This observation highlights another feature of our method: the binding motifs of a given CRM need not be explicitly known to identify co-regulated sequences since the entire sequence is used.

Such enriched motifs, if identified, are often believed to be the binding motifs of a common transcription factor (TF).

The presence of DNA binding motifs of a transcription factors' own in its promoter region, such as PDR3, YAP1, and HSF1, suggested a self-regulated expression.

Coding constraints can potentially limit the number of different protein binding motifs of a given type in the cell, in order to avoid non-specific cross recognition.