Sentence examples for binding motif did not from inspiring English sources

Similarly, site-directed mutagenesis of the c-Rel binding motif did not significantly alter hres gene promoter activity.

The scramble peptide, as well as other peptides with single mutation within the PDZ binding motif, did not show significant binding to the TIP-1 protein (Fig. 1E).

In contrast, W179C, a mutant form of α-HL (which has a mutation in Cav-1 binding motif) did not affect the caveolae dynamics (Video S5).

As shown in figure 7, full-length Podocalyxin showed strong colocalization with endogenous NHERF-1 at the apical membrane, while ΔDTHL and Δtail mutants, both of which lack the C-terminal NHERF binding motif, did not.

The presence of a consensus binding motif did not have an impact on whether a target gene was repressed or activated.

Interestingly, most of the peaks containing a PPARγ binding motif did not contain any DR4-type RE motif (79 of 87 peaks (90.8%) in the T09-treated and 162 of 173 peaks (93.6%) in the vehicle-treated peak set).

A splice variant of SKIP that lacks a light chain binding motif does not stimulate movement, suggesting fine-tuning by alternative splicing.

Hepcidin promoter constructs mirrored the response of mRNA levels to interleukin-6 and bone morphogenetic proteins, but not consistently to hypoxia or HIF stabilizers, and deletion of the putative HIF binding motifs did not alter the response to different hypoxic stimuli.

Wang et al. reported that TLS bind to RNA in the length dependent manner, and the mutation in the known binding motifs did not show a dramatic decrease in the binding [ 13], supporting the low specificity of the RNA binding of TLS.

Interestingly, a study by Roche and coworkers documented that phosphorylation of a PDZ-binding motif did not affect PDZ interactions: phosphorylation by PKA or PKC of the p -6) site within the C-terminus of the NR2C subunit of NMDAR did not change the binding of the p -695 PDZ3 or the siteace expression of NR1/NR2C NMDA receptors [ 127].

Nonetheless, the presence of in silico predicted binding motifs does not guarantee a specific regulatory factor will bind that sequence.