Sentence examples for binding motif are highly from inspiring English sources

Considering that the aPKC-binding region and the PDZ binding motif are highly conserved between species, the interaction between KIBRA and the polarity complex may be of fundamental importance to these organisms.

Our findings demonstrated that two Arc systems are significantly different from each other with respect to the physiological functions and the regulons although the sequences and binding motif are highly similar.

The EBF binding motif is highly enriched in active enhancers of adipogenesis and in brown adipose tissue-specific PPARγ binding sites [ 50, 57].

C/EBP and HNF3alpha, two families of transcription factors whose binding motifs are highly represented in GBRs of glucocorticoid-activated genes, were previously shown to act with GR to participate in glucocorticoid-activate gene transcription [59], [60], [61], [62].

For example, consensus binding motifs are highly enriched in genomic binding sites for the transcriptional repressor REST [7], whereas other factors, including the neuronal activity-regulated transcription factor CREB, are frequently found bound to regions that lack a consensus binding sequence [8].

However, other TFs binding motifs are highly enriched as well (Fig.  2i), supporting the general conclusion that ALKBH3 bound promoters are strongly regulated and transcriptionally active.

The LycRab5A protein, containing the ATPase/GTPase binding motifs and the effector molecules binding motifs, was highly homologous to that of other animals.

A characteristic PUF-binding motif was highly enriched among PUM bound messages and validated with RNA pull-down experiments.

This analysis revealed that the CHCC zinc-binding motif is highly conserved in the C-terminal domains of yeast dicers.

An alignment of ComFB homologues shows that the Zn-binding motif is highly conserved, with the fourth position being either cysteine or histidine.

Whereas the CHCC zinc-binding motif is highly conserved, the remaining sequences can be rather divergent even within the yeast group.