Sentence examples for binding modules such as from inspiring English sources

Analysis of the ADNP primary sequence does not reveal any of the characterized methyl-lysine binding modules such as chromo domains, PHD fingers or ankyrin repeats [62], [63].

Prominent among the factors, which showed maximum RNAi inhibition, are the members of DEAD-box family of RNA helicases, ABC transporter family, factor(s) possessing RNA binding module such as Integrator complex subunit (Int11) and a metabolic factor, isocitrate dehydrogenase.

Fourth, in the absence of cellulosomes, R. albus 7 and R. albus 8 may instead rely on alternate carbohydrate-binding modules, such as CBM37s, to facilitate coordination of secreted carbohydrases.

Het proteins like Het-E from Podospora anserina often harbor NACHT (NAIP, CIIA, HET-E, TP1) domains, or a highly divergent nucleoside phosphorylase (Pfs) linked with protein-binding modules such as Ankyrin repeats [ 25].

These NTP-binding proteins are often linked to various protein-binding modules such as WD40, Ankyrin or TPR at the C-terminus and a highly divergent nucleoside phosphorylase (Pfs) domain at their N-terminus (Fig. 3).

Chitinases (EC 3.2.1.14) are carbohydrate degrading enzymes that hydrolyze the β-(1 → 4 -glycosidic linkages in chitin, and are usually composed of a catalytic domain, one or more carbohydrate-binding modules (CBMs), and other modules, such as a fibronectin type III (FNIII) domain, but some chitinases have only a catalytic domain.

In the most recent study by Chanal et al. [ 20] the authors found that various scaffoldin modules, such as the family 3a carbohydrate binding module combined with the X2 modules from C. cellulolyticum or C. acetobutylicum, can trigger the secretion of larger cellulases when introduced to the cellulase as a carrier domain, but no further evidence for cellulose solubilisation was provided.

Notably, deletion of the six CohI modules did not substantially affect the profile of cellulolytic enzymes detected by SDS-PAGE in purified cellulosomes, either because the remaining two CohI modules in CipA provide sufficient binding capacity for these enzymes or because other proteins containing CohI modules (such as OlpA, OlpC) [ 40] can compensate for those missing from CipA.

A similar mechanism linking calcium-directed templating of PolyP-stimulated peptide synthesis could have produced the highly conserved modules, such as EF hands, made up of the dozen amino acids that form most calcium binding sites in modern proteins [ 135].

Protein interaction modules, such as PDZ, SH3, WW, EH, SH2 and other domains, mediate protein-protein interactions by recognizing and binding short and usually linear peptide epitopes within their interacting partners [1] [4].

They commonly have a catalytic domain (CD) that cleaves the glycosidic bond; carbohydrate-binding module (CBM) that targets the CD to the polysaccharide substrate; and, in many cases, additional types of ancillary modules such as FN3-like modules (Moraïs et al. 2012; Garvey et al. 2013).