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If the IREs function as composite binding modules for multiple transcription factors, then the chicken IRE-like element might contain a subset of the binding modules found in mammalian IREs as well as distinct modules.
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The ING PHD domains are specific and highly robust binding modules for H3K4me3 and H3K4me2.
RDKit has only preliminary support for Java bindings; when these are complete, a corresponding module will be added to Cinfony.
Several studies have shown that the tethering of multiple binding modules can enhance RNA-binding affinity and specificity, a strategy also commonly used in DNA recognition.
Thus, the C-terminus of H1 may encompass interaction module(s) for multiple binding partners of linker histone H1.
This creates binding sites for phosphotyrosine binding modules on signalling proteins, such as SH2 and phosphotyrosine-binding domains [ 1].
Protein arrays are thus useful tools for the comparative analysis of binding specificities of peptide binding modules.
The presence of multiple reader modules in chromatin modification complexes led to the proposal that distinct epigenetic signatures are interpreted by a multivalent reading process that engages diverse binding modules (Ruthenburg et al., 2007).
Cellulosomes were discovered in 1983 [ 3- 5] and are composed of non-catalytic scaffoldins, which contain a carbohydrate-binding module (CBM) for substrate targeting, as well as multiple cohesin modules for integrating dockerin-bearing enzymatic subunits to form a multi-component complex.
ESCRT-0, containing proteins with multiple Ub-binding modules, is the primary sensor for ubiquitinated membrane proteins.
For instance, the L binding module only contains the parameters k1 and k-1.
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